Use of Relatives of Cases as Controls to Identify Risk Factors when an Interaction between Environmental and Genetic Factors Exists | Zendy

Nadine Andrieu | Zendy; Alisa M. Goldstein | Zendy

Open Access

Use of Relatives of Cases as Controls to Identify Risk Factors when an Interaction between Environmental and Genetic Factors Exists

Author(s) -

Nadine Andrieu,

Alisa M. Goldstein

Publication year - 1996

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/25.3.649

Subject(s) - odds ratio , risk factor , case control study , odds , genetic predisposition , population , disease , gene–environment interaction , medicine , biology , genetics , environmental health , logistic regression , genotype , gene

The difficulty in detecting relevant risk factors for chronic diseases (such as breast and colon cancer) may be due to heterogeneity in the populations of studied cases, and one source of heterogeneity may be differential genetic susceptibility predisposing to differential environmental sensitivity.

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