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If pair members are independent, simple matched-pair case-control studies are known to yield consistent estimates of the population odds ratio. If pair members are not independent, this is not necessarily true. It has been shown previously that the usual matched-pair estimate remains consistent if the exposure of interest is correlated within the pairs. However, the effect of correlation of unmeasured risk factors within the pairs has not been studied.

Matched-Pair Case-Control Studies when Risk Factors are Correlated within the Pairs