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Barlow's disease is the most severe form of degenerative mitral valve disease, commonly characterized by bileaflet prolapse. Abnormal mitral annular dynamics is typically present and results in functional prolapse of the mitral leaflets that may be addressed with annular stabilization alone.

Mitral valve repair in Barlow’s disease with bileaflet prolapse: the effect of annular stabilization on functional mitral valve leaflet prolapse†