From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia | Zendy

David Hoogewijs | Zendy; Nora B. Terwilliger | Zendy; Keith A. Webster | Zendy; Jo Anne PowellCoffman | Zendy; S. Tokishita | Zendy; Hideo Yamagata | Zendy; Thomas Hankeln | Zendy; Thorsten Burmester | Zendy; Kalle T. Rytkönen | Zendy; Mikko Nikinmaa | Zendy; Doris Abele | Zendy; Kirstin-Friederike Heise | Zendy; Magnus Lucassen | Zendy; Joachim Fandrey | Zendy; Patrick H. Maxwell | Zendy; Sven Påhlman | Zendy; Thomas A. Gorr | Zendy

Open Access

From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

Author(s) -

David Hoogewijs,

Nora B. Terwilliger,

Keith A. Webster,

Jo Anne PowellCoffman,

S. Tokishita,

Hideo Yamagata,

Thomas Hankeln,

Thorsten Burmester,

Kalle T. Rytkönen,

Mikko Nikinmaa,

Doris Abele,

Kirstin-Friederike Heise,

Magnus Lucassen,

Joachim Fandrey,

Patrick H. Maxwell,

Sven Påhlman,

Thomas A. Gorr

Publication year - 2007

Publication title -

integrative and comparative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.328

H-Index - 123

eISSN - 1557-7023

pISSN - 1540-7063

DOI - 10.1093/icb/icm072

Subject(s) - bridging (networking) , hypoxia (environmental) , cancer research , biology , computational biology , microbiology and biotechnology , oxygen , computer science , chemistry , computer network , organic chemistry

The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O(2) sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.

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