Developmental Genes and the Reconstruction of Metazoan Evolution--Implications of Evolutionary Loss, Limits on Inference of Ancestry and Type 2 Errors | Zendy

David K. Jacobs | Zendy

Open Access

Developmental Genes and the Reconstruction of Metazoan Evolution--Implications of Evolutionary Loss, Limits on Inference of Ancestry and Type 2 Errors

Author(s) -

David K. Jacobs

Publication year - 2003

Publication title -

integrative and comparative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.328

H-Index - 123

eISSN - 1557-7023

pISSN - 1540-7063

DOI - 10.1093/icb/43.1.11

Subject(s) - engrailed , inference , biology , evolutionary biology , context (archaeology) , evolutionary developmental biology , phylogenetic tree , set (abstract data type) , phylogenetics , gene , genetics , computer science , artificial intelligence , homeobox , gene expression , paleontology , programming language

We consider three issues that appear to be important in the interpretation of developmental genetics in an evolutionary context. The three issues under discussion are 1) evolutionary loss as applied to evo-devo data; 2) the limits on our ability to infer ancestry based on tree reconstruction; and 3) "type 2" errors in the assessment of homology of developmental gene expression data. Lack of consideration of any or all of these disparate issues narrows the set of hypotheses under consideration. We examine these issues through examples drawing on new data on POU domain genes as well as through reference to published work on Distal-less, engrailed and Nk2 genes.

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