Inactive Rhomboid Protein 2 Mediates Intestinal Inflammation by Releasing Tumor Necrosis Factor–α | Zendy

Jee Hyun Kim | Zendy; Sung Wook Hwang | Zendy; Jaemoon Koh | Zendy; Jaeyoung Chun | Zendy; Changhyun Lee | Zendy; Jong Pil Im | Zendy; Joo Sung Kim | Zendy

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Inactive Rhomboid Protein 2 Mediates Intestinal Inflammation by Releasing Tumor Necrosis Factor–α

Author(s) -

Jee Hyun Kim,

Sung Wook Hwang,

Jaemoon Koh,

Jaeyoung Chun,

Changhyun Lee,

Jong Pil Im,

Joo Sung Kim

Publication year - 2019

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izz239

Subject(s) - rhomboid , inflammation , tumor necrosis factor alpha , tumor necrosis factor α , medicine , necrosis , cancer research , immunology , pathology , chemistry , biochemistry , enzyme , proteases

Inactive rhomboid 2 (iRhom2) is an essential molecule required for the maturation of tumor necrosis factor–α–converting enzyme in immune cells, which regulates TNF-α release. The aim of this study was to investigate the role of iRhom2 in intestinal inflammation.

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