Cerebral Vasculitis in Crohn's Disease: Always a Complication of Inflammatory Bowel Disease or Tumor Necrosis Factor–Alpha Inhibition? | Zendy

Tobias Moser | Zendy; Nele E Bubel | Zendy; Lukas Machegger | Zendy; Slaven Pikija | Zendy; Johann Sellner | Zendy

Open Access

Cerebral Vasculitis in Crohn's Disease: Always a Complication of Inflammatory Bowel Disease or Tumor Necrosis Factor–Alpha Inhibition?

Author(s) -

Tobias Moser,

Nele E Bubel,

Lukas Machegger,

Slaven Pikija,

Johann Sellner

Publication year - 2019

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izz231

Subject(s) - medicine , cerebral vasculitis , vasculitis , neuroborreliosis , infliximab , inflammatory bowel disease , complication , crohn's disease , tumor necrosis factor alpha , lyme neuroborreliosis , ulcerative colitis , stroke (engine) , gastroenterology , disease , pathology , immunology , antibody , borrelia burgdorferi , mechanical engineering , engineering

Cerebral vasculitis may be a complication of Crohn’s disease (CD) or a side-effect of therapies with biologics including tumor-necrosis factor-alpha antibodies. Here, we report a case of progressive brainstem syndrome and cranial polyneuritis in a patient with CD who had been treated with infliximab. We identified Lyme neuroborreliosis (LNB) as the cause of cerebral vasculitis and ischemic stroke and observed a favorable course following antibiotic treatment. Our case highlights the need for extensive search of causes of cerebral vasculitis in patients with CD and treatment with biologics.

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