Matrix-Delivered Autologous Mesenchymal Stem Cell Therapy for Refractory Rectovaginal Crohn’s Fistulas
Author(s) -
Amy L. Lightner,
Eric J. Dozois,
Allan B. Dietz,
Joel G. Fletcher,
Jessica Friton,
Greg W. Butler,
William A. Faubion
Publication year - 2019
Publication title -
inflammatory bowel diseases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izz215
Subject(s) - mesenchymal stem cell , refractory (planetary science) , medicine , crohn's disease , stem cell , disease , pathology , biology , astrobiology , genetics
Crohn's rectovaginal fistulizing disease remains notoriously difficult to treat. A phase I clinical trial to evaluate the safety and feasibility of a novel protocol using a mesenchymal stem cell (MSC)-coated Gore Bio-A fistula plug for the treatment of medically and surgically refractory Crohn's rectovaginal fistulas was conducted.
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