Identification of Key Pro-Survival Proteins in Isolated Colonic Goblet Cells of Winnie, a Murine Model of Spontaneous Colitis | Zendy

Richard Wilson | Zendy; Rohit Gundamaraju | Zendy; Ravichandra Vemuri | Zendy; Constanza Angelucci | Zendy; DP Geraghty | Zendy; Nuri Gueven | Zendy; Rajaraman Eri | Zendy

Open Access

Identification of Key Pro-Survival Proteins in Isolated Colonic Goblet Cells of Winnie, a Murine Model of Spontaneous Colitis

Author(s) -

Richard Wilson,

Rohit Gundamaraju,

Ravichandra Vemuri,

Constanza Angelucci,

DP Geraghty,

Nuri Gueven,

Rajaraman Eri

Publication year - 2019

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izz179

Subject(s) - mucin , endoplasmic reticulum , ulcerative colitis , colitis , proteomics , unfolded protein response , goblet cell , identification (biology) , microbiology and biotechnology , biology , immunology , medicine , pathology , disease , epithelium , biochemistry , gene , botany

This proteomics study reveals novel proteins and pathways that potentially underpin the survival and proliferation of goblet cells in the colon of Winnie mice, an ulcerative colitis model caused by misfolding of mucin-2 that results in endoplasmic reticulum stress.

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