Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation | Zendy

Thangaraj Karuppuchamy | Zendy; Christopher J. Tyler | Zendy; Luke Lundborg | Zendy; Tamara Pérez-Jeldres | Zendy; Abigail K. Kimball | Zendy; Eric T. Clambey | Zendy; Paul Jedlicka | Zendy; Jesús Rivera–Nieves | Zendy

Open Access

Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation

Author(s) -

Thangaraj Karuppuchamy,

Christopher J. Tyler,

Luke Lundborg,

Tamara Pérez-Jeldres,

Abigail K. Kimball,

Eric T. Clambey,

Paul Jedlicka,

Jesús Rivera–Nieves

Publication year - 2019

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izz174

Subject(s) - proinflammatory cytokine , biology , microbiology and biotechnology , sphingosine 1 phosphate , sphingosine , inflammation , immunology , receptor , biochemistry

Sphingosine-1-phosphate (S1P) receptor agonists are a promising therapeutic alternative to anti-integrin antibodies in inflammatory bowel disease. Here, we report that modulation of tissue S1P levels via inhibition of the S1P lyase might be an effective alternative, acting by interference with thymocyte maturation.

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