Open AccessIBD-Associated Dysplastic Lesions Show More Chromosomal Instability Than Sporadic Adenomas
Author(s) -
Linda K Wanders,
Martijn Cordes,
Quirinus J.M. Voorham,
Daoud Sie,
Sara de Vries,
Geert R. DʼHaens,
Nanne K.H. de Boer,
Bauke Ylstra,
Nicole C.T. van Grieken,
Gerrit A. Meijer,
Evelien Dekker,
Beatriz Carvalho
Publication year - 2019
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izz171
Subject(s) - chromosome instability , medicine , instability , microsatellite instability , biology , genetics , chromosome , physics , gene , allele , mechanics , microsatellite
Patients with longstanding inflammatory bowel disease (IBD; ie, ulcerative colitis and Crohn's disease) have an increased risk of colorectal cancer (CRC). Due to ongoing inflammation, IBD-associated dysplastic lesions can develop. These lesions have an increased risk to progress to cancer compared with sporadic adenomas, which are also found in these patients. Differentiating between these 2 types of dysplasia remains challenging, both clinically and histologically, while treatment strategies may differ. Therefore, the aim of this study was to investigate molecular alterations associated with colorectal dysplasia to cancer progression in IBD and evaluate to what extent these alterations differ from sporadic adenomas.
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