Open AccessDextran Sodium Sulfate-induced Colitis as a Model for Sarcopenia in Mice
Author(s) -
Dominik Saul,
Robyn Laura Kosinsky
Publication year - 2019
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1093/ibd/izz127
Subject(s) - sarcopenia , inflammation , medicine , inflammatory bowel disease , colitis , skeletal muscle , creatine kinase , gastrocnemius muscle , gastroenterology , endocrinology , disease
Forty-two percent of inflammatory bowel disease patients suffer from sarcopenia. We established a mouse model for this condition. Dextran sodium sulfate–induced colitis caused a severe decrease in muscle mass, fiber size, and the regulation of sarcopenia-associated key players on mRNA level.
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