Differentiation Between Pediatric Irritable Bowel Syndrome and Inflammatory Bowel Disease Based on Fecal Scent: Proof of Principle Study | Zendy

Sofie Bosch | Zendy; Nora van Gaal | Zendy; Roy Zuurbier | Zendy; James A. Covington | Zendy; Alfian Wicaksono | Zendy; Maarten H. Biezeveld | Zendy; Marc A. Benninga | Zendy; Chris J. Mulder | Zendy; Nanne K.H. de Boer | Zendy; Tim G. J. de Meij | Zendy

Open Access

Differentiation Between Pediatric Irritable Bowel Syndrome and Inflammatory Bowel Disease Based on Fecal Scent: Proof of Principle Study

Author(s) -

Sofie Bosch,

Nora van Gaal,

Roy Zuurbier,

James A. Covington,

Alfian Wicaksono,

Maarten H. Biezeveld,

Marc A. Benninga,

Chris J. Mulder,

Nanne K.H. de Boer,

Tim G. J. de Meij

Publication year - 2018

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izy151

Subject(s) - irritable bowel syndrome , medicine , gastroenterology , inflammatory bowel disease , ulcerative colitis , feces , abdominal pain , disease , paleontology , biology

The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs). The object of the study was to evaluate whether pediatric IBS/FAP-NOS could be discriminated from IBD and healthy controls by fecal VOC analysis.

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