Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice | Zendy

Jonathon Mitchell | Zendy; Su Jin Kim | Zendy; Γεώργιος Κούκος | Zendy; Alexandra Seelmann | Zendy; Brendan Veit | Zendy; Brooke Shepard | Zendy; Sara E. BlumerSchuette | Zendy; Harland S. Winter | Zendy; Dimitrios Iliopoulos | Zendy; Charalabos Pothoulakis | Zendy; Eunok Im | Zendy; Sang Hoon Rhee | Zendy

Open Access

Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice

Author(s) -

Jonathon Mitchell,

Su Jin Kim,

Γεώργιος Κούκος,

Alexandra Seelmann,

Brendan Veit,

Brooke Shepard,

Sara E. BlumerSchuette,

Harland S. Winter,

Dimitrios Iliopoulos,

Charalabos Pothoulakis,

Eunok Im,

Sang Hoon Rhee

Publication year - 2018

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izy124

Subject(s) - pten , colitis , tensin , inflammatory bowel disease , ulcerative colitis , intestinal mucosa , biology , cancer research , immunology , medicine , pi3k/akt/mtor pathway , disease , signal transduction , microbiology and biotechnology

Phosphatase and tensin homolog (Pten) is capable of mediating microbe-induced immune responses in the gut. Thus, Pten deficiency in the intestine accelerates colitis development in Il10-/- mice. As some ambient pollutants inhibit Pten function and exposure to ambient pollutants may increase inflammatory bowel disease (IBD) incidence, it is of interest to examine how Pten inhibition could affect colitis development in genetically susceptible hosts.

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