Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis | Zendy

M. Anthony Sofia | Zendy; Matthew A. Ciorba | Zendy; Katherine Meckel | Zendy; Chai K. Lim | Zendy; Gilles J. Guillemin | Zendy; Christopher R. Weber | Zendy; Marc Bissonnette | Zendy; Joel Pekow | Zendy

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Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis

Author(s) -

M. Anthony Sofia,

Matthew A. Ciorba,

Katherine Meckel,

Chai K. Lim,

Gilles J. Guillemin,

Christopher R. Weber,

Marc Bissonnette,

Joel Pekow

Publication year - 2018

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izy103

Subject(s) - kynurenine , kynurenine pathway , medicine , ulcerative colitis , metabolite , gastroenterology , inflammatory bowel disease , odds ratio , indoleamine 2,3 dioxygenase , inflammation , kynurenic acid , disease , tryptophan , chemistry , biochemistry , receptor , nmda receptor , amino acid

Mucosal appearance on endoscopy is an important indicator of inflammatory burden and determines prognosis in ulcerative colitis (UC). Inflammation induces tryptophan metabolism along the kynurenine pathway (KP) and yields immunologically relevant metabolites. We sought to examine whether changes in serum tryptophan metabolites and tissue expression of KP enzymes are associated with UC endoscopic and histologic disease severity.

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