The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter | Zendy

Rhian Stavely | Zendy; Sarah Fraser | Zendy; Shilpa Sharma | Zendy; Ahmed A. Rahman | Zendy; Vanesa Stojanovska | Zendy; Samy Sakkal | Zendy; Vasso Apostolopoulos | Zendy; Paul Bertrand | Zendy; Kulmira Nurgali | Zendy

Open Access

The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter

Author(s) -

Rhian Stavely,

Sarah Fraser,

Shilpa Sharma,

Ahmed A. Rahman,

Vanesa Stojanovska,

Samy Sakkal,

Vasso Apostolopoulos,

Paul Bertrand,

Kulmira Nurgali

Publication year - 2018

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1093/ibd/izy016

Subject(s) - enterochromaffin cell , serotonin , endocrinology , medicine , colitis , reuptake , ileum , serotonin transporter , jejunum , biology , receptor

Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious stimuli, inducing secretion of 5-HT, which plays an important role in enteric reflexes and immunomodulation. In this study, we evaluated intestinal 5-HT levels in the Winnie mouse model of spontaneous chronic colitis, which closely replicates UC.

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