Open AccessThe post-inner cell mass intermediate: implications for stem cell biology and assisted reproductive technology
Author(s) -
Margot Van der Jeught,
Thomas O’Leary,
Galbha Duggal,
Petra De Sutter,
Susana M. Chuva de Sousa Lopes,
Björn Heindryckx
Publication year - 2015
Publication title -
human reproduction update
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.977
H-Index - 180
eISSN - 1362-4946
pISSN - 1355-4786
DOI - 10.1093/humupd/dmv028
Subject(s) - epiblast , inner cell mass , embryonic stem cell , biology , stem cell , microbiology and biotechnology , induced pluripotent stem cell , developmental biology , cell , blastocyst , genetics , embryo , embryogenesis , gastrulation , gene
Until recently, the temporal events that precede the generation of pluripotent embryonic stem cells (ESCs) and their equivalence with specific developmental stages in vivo was poorly understood. Our group has discovered the existence of a transient epiblast-like structure, coined the post-inner cell mass (ICM) intermediate or PICMI, that emerges before human ESC (hESCs) are established, which supports their primed nature (i.e. already showing some predispositions towards certain cell types) of pluripotency.
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