Open AccessComparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding
Author(s) -
Enrrico Bloise,
Sky K. Feuer,
Paolo Rinaudo
Publication year - 2014
Publication title -
human reproduction update
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.977
H-Index - 180
eISSN - 1362-4946
pISSN - 1355-4786
DOI - 10.1093/humupd/dmu032
Subject(s) - assisted reproductive technology , fetus , medicine , pregnancy , disease , embryo , reproduction , physiology , obstetrics , gynecology , biology , infertility , pathology , genetics , ecology , microbiology and biotechnology
The number of children conceived using assisted reproductive technologies (ART) has reached >5 million worldwide and continues to increase. Although the great majority of ART children are healthy, many reports suggest a forthcoming risk of metabolic complications, which is further supported by the Developmental Origins of Health and Disease hypothesis of suboptimal embryo/fetal conditions predisposing adult cardiometabolic pathologies. Accumulating evidence suggests that fetal and placental growth kinetics are important features predicting post-natal health, but the relationship between ART and intrauterine growth has not been systematically reviewed.