The kisspeptin-GnRH pathway in human reproductive health and disease | Zendy

Karolina Skorupskaite | Zendy; Jyothis T. George | Zendy; Richard A. Anderson | Zendy

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The kisspeptin-GnRH pathway in human reproductive health and disease

Author(s) -

Karolina Skorupskaite,

Jyothis T. George,

Richard A. Anderson

Publication year - 2014

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmu009

Subject(s) - kisspeptin , neurokinin b , dynorphin , biology , endocrinology , medicine , regulator , gonadotropin releasing hormone , neuropeptide , hypogonadotropic hypogonadism , sex steroid , neuroscience , hormone , luteinizing hormone , receptor , opioid peptide , substance p , gene , steroid , biochemistry , opioid

The discovery of kisspeptin as key central regulator of GnRH secretion has led to a new level of understanding of the neuroendocrine regulation of human reproduction. The related discovery of the kisspeptin-neurokinin B-dynorphin (KNDy) pathway in the last decade has further strengthened our understanding of the modulation of GnRH secretion by endocrine, metabolic and environmental inputs. In this review, we summarize current understanding of the physiological roles of these novel neuropeptides, and discuss the clinical relevance of these discoveries and their potential translational applications.

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