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The human sperm cell is very well suited for proteomic studies, as it is accessible, can be easily purified and is believed to be transcriptionally and translationally silent. The recent use of advanced proteomic approaches is clearly challenging the understanding of sperm biology. The aims of this review are to discuss the various human sperm proteomic studies, to create a compiled list of all the sperm proteins described to date and to re-assess the potential functional implications.

The combined human sperm proteome: cellular pathways and implications for basic and clinical science