Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis | Zendy

Marie Misso | Zendy; Michael Costello | Zendy; Maria Garrubba | Zendy; Jennifer L. Wong | Zendy; Roger Hart | Zendy; Luk Rombauts | Zendy; Angela Melder | Zendy; Robert J. Norman | Zendy; Helena Teede | Zendy

Open Access

Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis

Author(s) -

Marie Misso,

Michael Costello,

Maria Garrubba,

Jennifer L. Wong,

Roger Hart,

Luk Rombauts,

Angela Melder,

Robert J. Norman,

Helena Teede

Publication year - 2012

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dms036

Subject(s) - polycystic ovary , metformin , medicine , miscarriage , meta analysis , infertility , gynecology , randomized controlled trial , obstetrics , pregnancy , clomifene , live birth , ovarian reserve , obesity , insulin resistance , insulin , biology , genetics

BACKGROUND Recent studies suggest that metformin may be more effective in women with polycystic ovary syndrome (PCOS) who are non-obese. The objective here is to determine and compare the effectiveness of metformin and clomiphene citrate for improving fertility outcomes in women with PCOS and a BMI < 32 kg/m(2) (BMI 32 kg/m(2) was used to allow for international differences in BMI values which determine access to infertility therapy through the public health system). METHODS Databases were searched for English language articles until July 2011.

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