Female reproduction and type 1 diabetes: from mechanisms to clinical findings | Zendy

Ethel Codner | Zendy; Paulina M. Merino | Zendy; Manuel TenaSempere | Zendy

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Female reproduction and type 1 diabetes: from mechanisms to clinical findings

Author(s) -

Ethel Codner,

Paulina M. Merino,

Manuel TenaSempere

Publication year - 2012

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dms024

Subject(s) - type 2 diabetes , reproduction , medicine , diabetes mellitus , biology , endocrinology , genetics

The functional reproductive alterations seen in women with type 1 diabetes (T1D) have changed as therapy has improved. Historically, patients with T1D and insufficient metabolic control exhibited a high prevalence of amenorrhea, hypogonadism and infertility. This paper reviews the impact of diabetes on the reproductive axis of female T1D patients treated with modern insulin therapy, with special attention to the mechanisms by which diabetes disrupts hypothalamic-pituitary-ovarian function, as documented mainly by animal model studies.

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