The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa | Zendy

Matthew D. Dun | Zendy; R. John Aitken | Zendy; Brett Nixon | Zendy

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The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa

Author(s) -

Matthew D. Dun,

R. John Aitken,

Brett Nixon

Publication year - 2012

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dms009

Subject(s) - spermatogenesis , biology , capacitation , sperm , spermatozoon , male infertility , microbiology and biotechnology , epididymis , chaperone (clinical) , andrology , infertility , genetics , endocrinology , medicine , pathology , pregnancy

Spermatogenesis culminates in production of one of the most highly differentiated cells in biology, the spermatozoon. The gametes that emerge from the testes are, however, functionally immature and only acquire full functionality once they have completed a process of post-testicular maturation in the epididymis and female reproductive tract. Remarkably, this acquisition of sperm function occurs while these cells are transcriptionally and translationally silent and is therefore highly dependent on post-translational modifications to their existing protein complement. In this review, we consider the emerging roles of several prominent molecular chaperone families in orchestrating both the morphological differentiation of male germ cells during spermatogenesis and their functional transformation during sperm maturation.

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