Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility | Zendy

Yun Miao | Zendy; Kumiko Kikuchi | Zendy; Qing Sun | Zendy; Heide Schatten | Zendy

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Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility

Author(s) -

Yun Miao,

Kumiko Kikuchi,

Qing Sun,

Heide Schatten

Publication year - 2009

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmp014

Subject(s) - oocyte , human fertilization , oocyte activation , andrology , embryo , biology , intracytoplasmic sperm injection , in vitro fertilisation , microbiology and biotechnology , medicine , genetics

In humans, normal healthy children are regularly produced through fertilization of fresh oocytes with fresh spermatozoa. However, asynchrony between oocytes and spermatozoa, especially when aged oocytes are fertilized by fresh or senescent spermatozoa, will not only affect the rate of fertilization and pre- and post-implantation embryo development but also the life of the offspring. As many failures in assisted reproduction technologies (ART) are related to oocyte aging, new methods are needed to control oocyte aging to benefit modern ART.

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