Growth hormone, menopause and ageing: no definite evidence for 'rejuvenation' with growth hormone | Zendy

Giuseppe Fanciulli | Zendy; Alessandro Delitala | Zendy; Giuseppe Delitala | Zendy

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Growth hormone, menopause and ageing: no definite evidence for 'rejuvenation' with growth hormone

Author(s) -

Giuseppe Fanciulli,

Alessandro Delitala,

Giuseppe Delitala

Publication year - 2009

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmp005

Subject(s) - menopause , estrogen , endocrinology , medicine , regimen , hormone , endocrine system , hormone replacement therapy (female to male) , growth hormone , testosterone (patch)

Estrogens regulate growth hormone (GH) secretion and modulate the tissue responsiveness to GH. After the menopause, and during ageing, a decline in GH secretion (somatopause) is physiologically observed. This article (i) provides a brief overview of the different regulators of GH secretion, (ii) reviews the mechanisms involved in age-related changes in GH concentrations, with particular emphasis on the interrelationships between menopause and GH, and (iii) discusses the interventions aimed at the restoration of GH and insulin-like growth factor (IGF-1) circulating levels.

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