The role of kisspeptin in the control of gonadotrophin secretion | Zendy

Antonia K. Roseweir | Zendy; Robert P. Millar | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The role of kisspeptin in the control of gonadotrophin secretion

Author(s) -

Antonia K. Roseweir,

Robert P. Millar

Publication year - 2008

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmn058

Subject(s) - kisspeptin , hypothalamic–pituitary–gonadal axis , biology , hypogonadotropic hypogonadism , endocrinology , medicine , signal transduction , neuroscience , luteinizing hormone , gonadotropin releasing hormone , hormone , microbiology and biotechnology

Kisspeptins, and their cognate receptor gpr-54, were first found to regulate the hypothalamic-pituitary-gonadal (HPG) axis in 2003, when two groups demonstrated that mutations in gpr-54 cause idiopathic hypogonadotropic hypogonadism characterized by delayed or absent puberty. This review aims to highlight discoveries in the KiSS-1/gpr-54 system, focusing on their regulation of the HPG axis in male and female reproductive systems of both mammalian and non-mammalian vertebrates.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research