The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis | Zendy

Caroline F. Wright | Zendy; H. Burton | Zendy

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The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis

Author(s) -

Caroline F. Wright,

H. Burton

Publication year - 2008

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmn047

Subject(s) - cell free fetal dna , fetus , clearance , nucleic acid , prenatal diagnosis , obstetrics , fetal circulation , pregnancy , gestation , medicine , biology , physiology , genetics , placenta , urology

Cell-free fetal nucleic acids (cffNA) can be detected in the maternal circulation during pregnancy, potentially offering an excellent method for early non-invasive prenatal diagnosis (NIPD) of the genetic status of a fetus. Using molecular techniques, fetal DNA and RNA can be detected from 5 weeks gestation and are rapidly cleared from the circulation following birth.

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