Non-genomic progesterone actions in female reproduction | Zendy

Birgit Gellersen | Zendy; Maria Sofia Fernandes | Zendy; Jan J. Brosens | Zendy

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Non-genomic progesterone actions in female reproduction

Author(s) -

Birgit Gellersen,

Maria Sofia Fernandes,

Jan J. Brosens

Publication year - 2008

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmn044

Subject(s) - reproduction , biology , progesterone receptor , medicine , gynecology , genetics , estrogen receptor , cancer , breast cancer

The steroid hormone progesterone is indispensable for mammalian procreation by controlling key female reproductive events that range from ovulation to implantation, maintenance of pregnancy and breast development. In addition to activating the progesterone receptors (PRs)-B and -A, members of the superfamily of ligand-dependent transcription factors, progesterone also elicits a variety of rapid signalling events independently of transcriptional or genomic regulation. This review covers our current knowledge on the mechanisms and relevance of non-genomic progesterone signalling in female reproduction.

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