Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis | Zendy

A.E. Nieuwenhuis-Ruifrok | Zendy; W. K. H. Kuchenbecker | Zendy; A. Hoek | Zendy; Philippa Middleton | Zendy; Robert J. Norman | Zendy

Open Access

Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis

Author(s) -

A.E. Nieuwenhuis-Ruifrok,

W. K. H. Kuchenbecker,

A. Hoek,

Philippa Middleton,

Robert J. Norman

Publication year - 2008

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmn043

Subject(s) - medicine , polycystic ovary , metformin , weight loss , overweight , body mass index , infertility , obesity , randomized controlled trial , placebo , pregnancy , gynecology , meta analysis , insulin , insulin resistance , alternative medicine , pathology , biology , genetics

Women of reproductive age, who are overweight or obese, are prone to infertility. Weight loss in these women leads to increased fecundity, higher chances of conception after infertility treatment and improved pregnancy outcome. In spite of the advantages, most patients have difficulty in losing weight and often regain lost weight over time. This review assesses whether treatment with insulin sensitizing drugs contributes to weight loss, compared with diet or a lifestyle modification programme.

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