Impacts of platinum-based chemotherapy on subsequent testicular function and fertility in boys with cancer | Zendy

Lim Tian En | Zendy; Mark Brougham | Zendy; William H. Wallace | Zendy; Rod T. Mitchell | Zendy

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Impacts of platinum-based chemotherapy on subsequent testicular function and fertility in boys with cancer

Author(s) -

Lim Tian En,

Mark Brougham,

William H. Wallace,

Rod T. Mitchell

Publication year - 2020

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmaa041

Subject(s) - testicular cancer , medicine , infertility , fertility , cancer , chemotherapy , oncology , cyclophosphamide , fertility preservation , germ cell tumors , gynecology , pregnancy , population , biology , environmental health , genetics

Children with cancer often face infertility as a long-term complication of their treatment. For boys, compromised testicular function is common after chemotherapy and currently there are no well-established options to prevent this damage. Platinum-based agents are used to treat a wide variety of childhood cancers. However, platinum agents are not currently included in the cyclophosphamide equivalent dose (CED), which is used clinically to assess the risks to fertility posed by combination chemotherapy in children with cancer.

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