DNA methylation in human sperm: a systematic review | Zendy

Fredrika Åsenius | Zendy; Amy F. Danson | Zendy; Sarah J. Marzi | Zendy

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DNA methylation in human sperm: a systematic review

Author(s) -

Fredrika Åsenius,

Amy F. Danson,

Sarah J. Marzi

Publication year - 2020

Publication title -

human reproduction update

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.977

H-Index - 180

eISSN - 1362-4946

pISSN - 1355-4786

DOI - 10.1093/humupd/dmaa025

Subject(s) - dna methylation , biology , methylation , semen quality , andrology , offspring , cochrane library , sperm , epigenetics , male infertility , bioinformatics , genetics , infertility , medicine , medline , dna , pregnancy , gene , gene expression , biochemistry

Studies in non-human mammals suggest that environmental factors can influence spermatozoal DNA methylation, and some research suggests that spermatozoal DNA methylation is also implicated in conditions such as subfertility and imprinting disorders in the offspring. Together with an increased availability of cost-effective methods of interrogating DNA methylation, this premise has led to an increasing number of studies investigating the DNA methylation landscape of human spermatozoa. However, how the human spermatozoal DNA methylome is influenced by environmental factors is still unclear, as is the role of human spermatozoal DNA methylation in subfertility and in influencing offspring health.

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