Open AccessEndometriosis and unexplained recurrent spontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function?
Author(s) -
Edgardo Somigliana
Publication year - 1999
Publication title -
human reproduction update
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.977
H-Index - 180
eISSN - 1362-4946
pISSN - 1355-4786
DOI - 10.1093/humupd/5.1.40
Subject(s) - endometriosis , pathological , abortion , medicine , natural killer cell , function (biology) , immunology , bioinformatics , biology , gynecology , pathology , pregnancy , microbiology and biotechnology , genetics , cytotoxicity , in vitro
The observation that natural killer (NK) cell activity is abnormally low in endometriosis patients and abnormally high in women with otherwise unexplained recurrent spontaneous abortion represents, at present, an intriguing curiosity. There is evidence suggesting that these conditions are associated with an opposite regulation of NK cell behaviour. This review discusses these observations and potential relationships.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom