Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused byGNRHRmutations and women with polycystic ovary syndrome
Author(s) -
Luigi Maione,
Anne Fèvre,
Immacolata Cristiettore,
Ashmeetha Manilall,
Bruno Francou,
Séverine Trabado,
Jérôme Bouligand,
Anne GuiochonMantel,
Brigitte Delemer,
Colleen A. Flanagan,
Paolo Emidio Macchia,
Robert P. Millar,
Jacques Young
Publication year - 2018
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dey339
Subject(s) - gnrhr , hypogonadotrophic hypogonadism , polycystic ovary , medicine , hypogonadotropic hypogonadism , delayed puberty , endocrinology , amenorrhea , gynecology , gonadotropin releasing hormone , luteinizing hormone , biology , hormone , insulin resistance , pregnancy , genetics , diabetes mellitus
Does the phenotype of women with normosmic congenital hypogonadotrophic hypogonadism (nCHH) and pituitary resistance to GnRH caused by biallelic mutations in the GnRH receptor (GNRHR) (nCHH/bi-GNRHR) differ from that of women with polycystic ovary syndrome (PCOS)?
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