Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling | Zendy

Martine Cools | Zendy; Katja P. Wolffenbuttel | Zendy; Remko Hersmus | Zendy; Berenice B. Mendonça | Zendy; Jana Kaprova | Zendy; Stenvert L. S. Drop | Zendy; Hans Stoop | Zendy; Ad Gillis | Zendy; J. Wolter Oosterhuis | Zendy; Elaine Maria Frade Costa | Zendy; Sorahia Domenice | Zendy; Mirian Yumie Nishi | Zendy; Lutz Wünsch | Zendy; Cliodhna Quigley | Zendy; Guy T’Sjoen | Zendy; Leendert H. J. Looijenga | Zendy

Open Access

Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling

Author(s) -

Martine Cools,

Katja P. Wolffenbuttel,

Remko Hersmus,

Berenice B. Mendonça,

Jana Kaprova,

Stenvert L. S. Drop,

Hans Stoop,

Ad Gillis,

J. Wolter Oosterhuis,

Elaine Maria Frade Costa,

Sorahia Domenice,

Mirian Yumie Nishi,

Lutz Wünsch,

Cliodhna Quigley,

Guy T’Sjoen,

Leendert H. J. Looijenga

Publication year - 2017

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dex300

Subject(s) - testicular germ cell tumor , single nucleotide polymorphism , oncology , genome wide association study , snp , genetic predisposition , biology , medicine , testicular cancer , genotype , genetics , cancer , gene , disease

What is the prevalence of malignant testicular germ cell tumors (TGCT) and its precursors, (pre-) germ cell neoplasia in situ (GCNIS), in late teenagers and adults who have androgen insensitivity syndrome (AIS) and the impact of an individual's genetic susceptibility to development of TGCT?

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