miR-196a overexpression activates the MEK/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis | Zendy

Min Zhou | Zendy; Jing Fu | Zendy; Li Xiao | Zendy; Shiyuan Yang | Zendy; Yong Song | Zendy; Xianghui Zhang | Zendy; Xue Feng | Zendy; Huaqin Sun | Zendy; Wenming Xu | Zendy; Wei Huang | Zendy

Open Access

miR-196a overexpression activates the MEK/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis

Author(s) -

Min Zhou,

Jing Fu,

Li Xiao,

Shiyuan Yang,

Yong Song,

Xianghui Zhang,

Xue Feng,

Huaqin Sun,

Wenming Xu,

Wei Huang

Publication year - 2016

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dew223

Subject(s) - endometrium , decidualization , endometriosis , progesterone receptor , mapk/erk pathway , microrna , stromal cell , biology , downregulation and upregulation , microarray analysis techniques , microarray , medicine , endocrinology , cancer research , andrology , gene expression , signal transduction , microbiology and biotechnology , gene , estrogen receptor , cancer , biochemistry , breast cancer

Do microRNAs (miRNAs) contribute to aberrant progesterone receptor (PGR) expression in the eutopic endometrium of women with endometriosis? SUMMARY ANSWER: miR-196a upregulates MEK/ERK signalling, mediating a downregulation of PGR expression in the eutopic endometrium of women with minimal or mild endometriosis.

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