Open AccessCharacterization of anastrozole effects, delivered by an intravaginal ring in cynomolgus monkeys
Author(s) -
Andrea Rotgeri,
H. Korolainen,
O. SUNDHOLM,
H. Schmitz,
U. Fuhrmann,
Katja Prelle,
Frank Sacher
Publication year - 2014
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deu315
Subject(s) - pharmacokinetics , aromatase , pharmacology , in vivo , pharmacodynamics , anastrozole , estrogen , medicine , drug , menstrual cycle , aromatase inhibitor , endocrinology , biology , hormone , microbiology and biotechnology , cancer , breast cancer
Is it feasible to deliver anastrozole (ATZ), an aromatase inhibitor (AI), by a vaginal polymer-based drug delivery system in the cynomolgus monkey (Macaca fascicularis) to describe the pharmacokinetic profile?
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