First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient | Zendy

Ethiraj Balaji Prasath | Zendy; Melinda Chan | Zendy; WL Wong | Zendy; Cheryl Lim | Zendy; Melissa D. Tharmalingam | Zendy; Marianne S. Hendricks | Zendy; S. F. Loh | Zendy; Y. Chia | Zendy

Open Access

First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient

Author(s) -

Ethiraj Balaji Prasath,

Melinda Chan,

WL Wong,

Cheryl Lim,

Melissa D. Tharmalingam,

Marianne S. Hendricks,

S. F. Loh,

Y. Chia

Publication year - 2013

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/det420

Subject(s) - live birth , pregnancy , fertility preservation , gynecology , in vitro fertilisation , cryopreservation , medicine , embryo cryopreservation , andrology , oophorectomy , fertility , oocyte cryopreservation , in vitro maturation , obstetrics , ovarian cancer , embryo , biology , cancer , oocyte , hysterectomy , surgery , population , genetics , environmental health , microbiology and biotechnology

In vitro maturation (IVM) of immature oocytes retrieved from surgically resected ovaries has been proposed as a method of fertility preservation in ovarian cancer patients undergoing definitive surgery. While there had been several reports of successful derivation of mature oocytes and or embryos, there have been no reports as yet of successful pregnancies. In this case report, we present a pregnancy and live birth from a young patient, with stage IIIC ovarian cancer, who had undergone fertility sparing surgery. The immature oocytes recovered after oophorectomy were fertilized after IVM. The embryos obtained were cryopreserved and later transferred to achieve a singleton healthy pregnancy leading to a live birth.

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