Treatment of human embryos with the TGF inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation | Zendy

Margot Van der Jeught | Zendy; Björn Heindryckx | Zendy; Thomas O’Leary | Zendy; Galbha Duggal | Zendy; Sabitri Ghimire | Zendy; Sylvie Lierman | Zendy; Nadine Van Roy | Zendy; Susana M. Chuva de Sousa Lopes | Zendy; Tom Deroo | Zendy; Dieter Deforce | Zendy; Petra De Sutter | Zendy

Open Access

Treatment of human embryos with the TGF inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation

Author(s) -

Margot Van der Jeught,

Björn Heindryckx,

Thomas O’Leary,

Galbha Duggal,

Sabitri Ghimire,

Sylvie Lierman,

Nadine Van Roy,

Susana M. Chuva de Sousa Lopes,

Tom Deroo,

Dieter Deforce,

Petra De Sutter

Publication year - 2013

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/det400

Subject(s) - epiblast , homeobox protein nanog , embryonic stem cell , inner cell mass , andrology , nanog homeobox protein , immunocytochemistry , rex1 , embryo , biology , microbiology and biotechnology , stem cell , blastocyst , immunology , embryogenesis , sox2 , endocrinology , medicine , gastrulation , induced pluripotent stem cell , genetics , gene

Is there an effect of the TGFβ inhibitor SB431542 (SB) on the epiblast compartment of human blastocysts, and does it affect subsequent human embryonic stem cell (hESC) derivation?

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