A novel cell-processing method 'AgarCytos' in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens | Zendy

M. Hessel | Zendy; Liliana Ramos | Zendy; A. F. C. Hulsbergen | Zendy; Kathleen D’Hauwers | Zendy; D.D.M. Braat | Zendy; Christina A. Hulsbergenvan de Kaa | Zendy

Open Access

A novel cell-processing method 'AgarCytos' in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

Author(s) -

M. Hessel,

Liliana Ramos,

A. F. C. Hulsbergen,

Kathleen D’Hauwers,

D.D.M. Braat,

Christina A. Hulsbergenvan de Kaa

Publication year - 2013

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/det311

Subject(s) - testicular sperm extraction , azoospermia , sperm retrieval , germ cell , andrology , biology , placental alkaline phosphatase , seminoma , sperm , testicle , alkaline phosphatase , medicine , infertility , anatomy , pregnancy , genetics , chemotherapy , biochemistry , gene , enzyme

Can we diagnose intratubular germ cell neoplasia (IGCN) using the immunohistochemical markers placental-like alkaline phosphatase (PLAP) and OCT3/4 using a novel cell-processing method 'AgarCytos', applied to the remnants of testicular sperm extraction (TESE) specimens and what is the prevalence of a testicular germ cell (pre)malignancy in men with a non-obstructive azoospermia (NOA) undergoing TESE for fertility treatment?

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