Open AccessTargeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas
Author(s) -
S. Nair,
David T. Curiel,
V.S. Rajaratnam,
Chandrasekhar Thota,
Ayman AlHendy
Publication year - 2013
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/det275
Subject(s) - genetic enhancement , uterine leiomyoma , viral vector , leiomyoma , cancer research , gene transfer , medicine , gene , virology , uterus , biology , pathology , genetics , recombinant dna
Is targeted adenovirus vector, Ad-SSTR-RGD-TK (Adenovirus -human somatostatin receptor subtype 2- arginine, glycine and aspartate-thymidine kinase), given in combination with ganciclovir (GCV) against immortalized human leiomyoma cells (HuLM) a potential therapy for uterine fibroids?
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