Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility | Zendy

Frédéric Chalmel | Zendy; Aurélie Lardenois | Zendy; Bertrand Evrard | Zendy; Romain Mathiéu | Zendy; Caroline Feig | Zendy; Philippe Demougin | Zendy; Alexandre Gattiker | Zendy; Wolfgang Schulze | Zendy; Bernard Jégou | Zendy; Christiane Kirchhoff | Zendy; Michael Primig | Zendy

Open Access

Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility

Author(s) -

Frédéric Chalmel,

Aurélie Lardenois,

Bertrand Evrard,

Romain Mathiéu,

Caroline Feig,

Philippe Demougin,

Alexandre Gattiker,

Wolfgang Schulze,

Bernard Jégou,

Christiane Kirchhoff,

Michael Primig

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des301

Subject(s) - biology , germline , somatic cell , germ cell , interactome , transcriptome , genetics , gene expression profiling , male infertility , gene , gametogenesis , phenotype , gene expression , infertility , embryogenesis , pregnancy

Mammalian spermatogenesis is a process that involves a complex expression program in both somatic and germ cells present in the male gonad. A number of studies have attempted to define the transcriptome of male meiosis and gametogenesis in rodents and primates. Few human transcripts, however, have been associated with testicular somatic cells and germ cells at different post-natal developmental stages and little is known about their level of germline-specificity compared with non-testicular tissues.

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