Open AccessMethylation profile of the promoters of Nanog and Oct4 in ICSI human embryos
Author(s) -
Mohamed Al-Khtib,
Thierry Blachère,
J.-F. Guerin,
A. Lefèvre
Publication year - 2012
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/des284
Subject(s) - homeobox protein nanog , reprogramming , biology , methylation , promoter , nanog homeobox protein , andrology , inner cell mass , blastocyst , dna methylation , embryo , embryonic stem cell , genetics , induced pluripotent stem cell , embryogenesis , gene , medicine , gene expression
What is the methylation status of the Nanog and Oct4 promoters in human gametes and ICSI embryos and is abnormal reprogramming of their methylation associated with developmental failure of ICSI embryos?
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