Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF- B/COX-2/PGE2 | Zendy

Jing Chen | Zendy; Kin Lam Fok | Zendy; Haiyong Chen | Zendy; Xiaohu Zhang | Zendy; Wei Xu | Zendy; Hsiao Chang Chan | Zendy

Open Access

Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF- B/COX-2/PGE2

Author(s) -

Jing Chen,

Kin Lam Fok,

Haiyong Chen,

Xiaohu Zhang,

Wei Xu,

Hsiao Chang Chan

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des254

Subject(s) - sertoli cell , tight junction , spermatogenesis , blood–testis barrier , endocrinology , medicine , cystic fibrosis transmembrane conductance regulator , epididymis , prostaglandin , andrology , nf κb , biology , microbiology and biotechnology , chemistry , signal transduction , cystic fibrosis , sperm

Does elevated temperature-induced cystic fibrosis transmembrane conductance regulator (CFTR) down-regulation in Sertoli cells in cryptorchid testis disrupt testicular tight junctions (TJs) through the nuclear factor kappa B (NF-κB)/cyclooxygenase-2 (COX-2)/prostaglandin E(2) (PGE(2)) pathway?

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