Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis | Zendy

SeyedehFaezeh Moraveji | Zendy; Farnoosh Attari | Zendy; Abdolhossein Shahverdi | Zendy; Houri Sepehri | Zendy; Ali Farrokhi | Zendy; SeyedehNafiseh Hassani | Zendy; Hananeh Fonoudi | Zendy; Nasser Aghdami | Zendy; Hossein Baharvand | Zendy

Open Access

Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis

Author(s) -

SeyedehFaezeh Moraveji,

Farnoosh Attari,

Abdolhossein Shahverdi,

Houri Sepehri,

Ali Farrokhi,

SeyedehNafiseh Hassani,

Hananeh Fonoudi,

Nasser Aghdami,

Hossein Baharvand

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des204

Subject(s) - gsk 3 , induced pluripotent stem cell , biology , stem cell , microbiology and biotechnology , embryonic stem cell , glycogen synthase , gsk3b , kinase , endocrinology , glycogen , medicine , biochemistry , gene

Several studies have demonstrated the derivation of multi- or pluripotent stem cells from testicular cells of both newborn and adult mice by a spontaneous conversion process, when these cells are cultured in vitro for an extended time. To obtain a better and robust derivation, we have attempted to identify small molecules (SMs) that induce reprogramming of testicular cells in culture into germline-derived pluripotent stem cells (gPSCs).

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