Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies | Zendy

Hitoshi Hiura | Zendy; Hiroaki Okae | Zendy; Naoko Miyauchi | Zendy; Fumi Sato | Zendy; Akiko Satô | Zendy; Mathew Van de Pette | Zendy; Rosalind M. John | Zendy; Masayo Kagami | Zendy; Kunihiko Nakai | Zendy; Hidenobu Soejima | Zendy; Tsutomu Ogata | Zendy; Takahiro Arima | Zendy

Open Access

Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies

Author(s) -

Hitoshi Hiura,

Hiroaki Okae,

Naoko Miyauchi,

Fumi Sato,

Akiko Satô,

Mathew Van de Pette,

Rosalind M. John,

Masayo Kagami,

Kunihiko Nakai,

Hidenobu Soejima,

Tsutomu Ogata,

Takahiro Arima

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des197

Subject(s) - imprinting (psychology) , genomic imprinting , dna methylation , epigenetics , biology , genetics , methylation , beckwith–wiedemann syndrome , bisulfite sequencing , dna , gene , gene expression

There is an increased incidence of rare imprinting disorders associated with assisted reproduction technologies (ARTs). The identification of epigenetic changes at imprinted loci in ART infants has led to the suggestion that the techniques themselves may predispose embryos to acquire imprinting errors and diseases. However, it is still unknown at what point(s) these imprinting errors arise, or the risk factors.

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