Higher clusterin immunolabeling and sperm DNA damage levels in hypertensive men compared with controls | Zendy

Barbara Muciaccia | Zendy; Simona Pensini | Zendy; Franco Culasso | Zendy; Fabrizio Padula | Zendy; Donatella Paoli | Zendy; L. Gandini | Zendy; Claudio Di Veroli | Zendy; G Bianchini | Zendy; Mario Stefanini | Zendy; A. D'Agostino | Zendy

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Higher clusterin immunolabeling and sperm DNA damage levels in hypertensive men compared with controls

Author(s) -

Barbara Muciaccia,

Simona Pensini,

Franco Culasso,

Fabrizio Padula,

Donatella Paoli,

L. Gandini,

Claudio Di Veroli,

G Bianchini,

Mario Stefanini,

A. D'Agostino

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des173

Subject(s) - dna fragmentation , immunolabeling , sperm , clusterin , andrology , biology , tunel assay , sperm motility , endocrinology , medicine , apoptosis , immunohistochemistry , immunology , programmed cell death , genetics

Clusterin, a heterodimeric glycoprotein found at several sites in the human male reproductive tract, could be a marker of morphologically abnormal spermatozoa, while TUNEL positivity indicates DNA fragmentation. Metabolic disorders such as diabetes mellitus and obesity may compromise sperm quality and fertility of men; however, little evidence specifically links hypertension with the impairment of male reproductive function.

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