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In a previous study, we found that amifostine provides some protection to the seminiferous epithelium of prepubertal doxorubicin-treated male rats but does not improve their fertility status as adults. Based on these results, a long-term study was undertaken to evaluate the DNA damage caused to spermatogonia and the consequences for embryo development.

Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest