Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest | Zendy

Vanessa Vendramini | Zendy; Bernard Robaire | Zendy; Sandra Maria Miraglia | Zendy

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Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest

Author(s) -

Vanessa Vendramini,

Bernard Robaire,

Sandra Maria Miraglia

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des159

Subject(s) - amifostine , andrology , spermatogenesis , biology , comet assay , sperm , embryo , bleomycin , dna damage , doxorubicin , medicine , endocrinology , dna , genetics , chemotherapy

In a previous study, we found that amifostine provides some protection to the seminiferous epithelium of prepubertal doxorubicin-treated male rats but does not improve their fertility status as adults. Based on these results, a long-term study was undertaken to evaluate the DNA damage caused to spermatogonia and the consequences for embryo development.

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