Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of the rhesus macaque | Zendy

M Peluffo | Zendy; Alison Y. Ting | Zendy; A.M. Zamah | Zendy; Marco Conti | Zendy; Richard L. Stouffer | Zendy; Mary B. Zelinski | Zendy; Jon D. Hennebold | Zendy

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Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of the rhesus macaque

Author(s) -

M Peluffo,

Alison Y. Ting,

A.M. Zamah,

Marco Conti,

Richard L. Stouffer,

Mary B. Zelinski,

Jon D. Hennebold

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des158

Subject(s) - amphiregulin , antral follicle , rhesus macaque , biology , andrology , antrum , microbiology and biotechnology , medicine , virology , endocrinology , genetics , ovary , epidermal growth factor , cell culture , biochemistry , stomach

In non-primates, the epidermal growth factor (EGF) and EGF-related ligands such as amphiregulin (AREG) serve as critical intermediates between the theca/mural cells and the cumulus-oocyte-complex (COC) following the mid-cycle LH surge. Studies were designed in primates (1) to analyze AREG levels in follicular fluid (follicular fluid) obtained from pre-ovulatory follicles, as well as (2) to assess dose-dependent effects of AREG on oocytes from small antral follicles (SAFs) during culture, including meiotic and cytoplasmic maturation.

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