Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa | Zendy

Pilar Coy | Zendy; María JiménezMovilla | Zendy; Francisco Alberto GarcíaVázquez | Zendy; Irene Mondéjar | Zendy; Luis Alberto Grullón | Zendy; Raquel Romar | Zendy

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Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa

Author(s) -

Pilar Coy,

María JiménezMovilla,

Francisco Alberto GarcíaVázquez,

Irene Mondéjar,

Luis Alberto Grullón,

Raquel Romar

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des146

Subject(s) - plasmin , oocyte , andrology , sperm , human fertilization , semen , biology , chemistry , medicine , microbiology and biotechnology , anatomy , embryo , biochemistry , enzyme

The role of the plasminogen-plasmin (PLG-PLA) system in fertilization is unknown, although its dysfunction has been associated with subfertility in humans. We have recently detected and quantified plasminogen in the oviductal fluid of two mammals and showed a reduction in sperm penetration during IVF when plasminogen is present. The objective of this study was to describe the mechanism by which PLG-PLA system regulates sperm entry into the oocyte.

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