Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility | Zendy

Marta Annunziata | Zendy; Raúl M. Luque | Zendy; Mario DuránPrado | Zendy; Alessandra Baragli | Zendy; Cristina Grande | Zendy; Marco Volante | Zendy; Manuel D. Gahete | Zendy; Francesco Deltetto | Zendy; Marco Camanni | Zendy; Ezio Ghigo | Zendy; Justo P. Castaño | Zendy; Riccarda Granata | Zendy

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Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility

Author(s) -

Marta Annunziata,

Raúl M. Luque,

Mario DuránPrado,

Alessandra Baragli,

Cristina Grande,

Marco Volante,

Manuel D. Gahete,

Francesco Deltetto,

Marco Camanni,

Ezio Ghigo,

Justo P. Castaño,

Riccarda Granata

Publication year - 2012

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/des144

Subject(s) - platelet derived growth factor receptor , cell growth , biology , somatostatin , stromal cell , motility , cancer research , growth factor , microbiology and biotechnology , endocrinology , receptor , biochemistry

Endometriosis is characterized by ectopic implantation of endometrial cells, which show increased proliferation and migration. Somatostatin (SST) and its analogues inhibit normal and cancer cell growth and motility through the SST receptors, sst1-5. Cortistatin (CST), which displays high structural and functional homology with SST, binds all ssts, as well as MrgX2. Our objective was to investigate the gene expression of the SST/CST system and to determine the effect of SST and its analogues on platelet-derived growth factor (PDGF)-induced proliferation and motility in telomerase-immortalized human endometrial stromal cell (T HESC) line and in primary endometrial stromal cell (ESCs) isolated from human endometriotic tissues.

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